Creamy Southwest Chicken Alfredo: A Flavorful Twist on a Classic

A bowl of Creamy Southwest Chicken Alfredo pasta garnished with fresh herbs.

Dive into the rich and creamy world of our Southwest Chicken Alfredo, a dish that promises to elevate your pasta nights to new heights of flavor. This recipe brings a delightful twist to the classic Alfredo, infusing it with the bold and vibrant tastes of the Southwest. Perfect for those who love a bit of spice in their life, this dish combines tender chicken strips, colorful bell peppers, and cherry tomatoes, all tossed in a smoky, creamy sauce. Whether you’re looking to impress guests or simply spice up your dinner routine, this Southwest Chicken Alfredo is sure to become a new favorite.

Why You’ll Love This Southwest Chicken Alfredo?

Our Southwest Chicken Alfredo is not just another pasta dish; it’s a culinary adventure that brings together the best of creamy comfort and zesty flavors. Here’s why you’ll fall in love with this recipe:

  • It’s incredibly flavorful, with smoked paprika and chili powder adding a unique depth to the Alfredo sauce.
  • The colorful mix of bell peppers and cherry tomatoes not only adds a pop of color but also a fresh, slightly sweet contrast to the creamy sauce.
  • It’s versatile and can be customized to your heat preference, making it a hit for all palates.

Ingredients and Step-by-Step Instructions:


  • 8 ounces fettuccine pasta
  • 2 boneless, skinless chicken breasts, sliced into strips
  • 2 tablespoons olive oil
  • 2 cloves garlic, minced
  • 1 red bell pepper, thinly sliced
  • 1 yellow bell pepper, thinly sliced
  • 1 cup cherry tomatoes, halved
  • 1 cup heavy cream
  • 1/2 cup grated Parmesan cheese
  • 1 teaspoon smoked paprika
  • 1/2 teaspoon chili powder
  • Salt and pepper to taste
  • Fresh cilantro or parsley for garnish (optional)


  1. Cook the fettuccine pasta to al dente as per package instructions, drain, and set aside.For those looking to perfect their pasta cooking skills to complement dishes like Southwest Chicken Alfredo, or seeking another comforting pasta dish for busy weeknights, check out our delicious Chili Mac Recipe. Additional additional guidance, Food Network’s “How to Cook Pasta” provides a step-by-step guide that can help readers navigate the nuances of pasta cooking, ensuring a flawless base for any pasta dish. Explore further pasta cooking techniques.
  2. In a large skillet, heat olive oil over medium-high. Cook the chicken strips until browned and cooked through, about 5-6 minutes, then set aside.
  3. Sauté minced garlic in the same skillet for 1-2 minutes until fragrant.
  4. Add bell peppers, cooking until softened, about 3-4 minutes, then include cherry tomatoes for an additional 2 minutes.
  5. Lower heat to medium-low, add heavy cream, Parmesan, smoked paprika, chili powder, salt, and pepper, cooking until sauce thickens, about 3-4 minutes.
  6. Combine chicken and pasta in the skillet, tossing in the sauce until well coated.
  7. Garnish with cilantro or parsley if desired, and serve hot.

Tips for the Perfect Southwest Chicken Alfredo:

  • For an extra kick, adjust the amount of chili powder according to your taste.
  • Ensure not to overcook the pasta; al dente pasta holds up better in the sauce.
  • For a lighter version, substitute half-and-half for the heavy cream, though this may affect the sauce’s richness.

Serving Suggestions:

Serve this mouthwatering Southwest Chicken Alfredo with a side of garlic bread or a crisp green salad to balance the creamy richness of the dish. For a complete meal, consider pairing it with a glass of your favorite white wine, which complements the creamy sauce beautifully.

Nutritional Information (Per Serving):

  • Servings: 4
  • Calories: 480 kcal
  • Protein: 27 g
  • Carbohydrates: 47 g
  • Fat: 22 g
  • Saturated Fat: 11 g
  • Cholesterol: 125 mg
  • Sodium: 390 mg
  • Fiber: 3 g
  • Sugar: 5 g

Note: Nutritional values are approximate and may vary based on specific ingredients used.


Our Creamy Southwest Chicken Alfredo is more than just a meal; it’s a celebration of flavors that brings warmth and joy to your table. With its creamy texture, smoky spices, and vibrant vegetables, this dish is sure to impress anyone who tries it. So why wait? Dive into this delicious adventure and let your taste buds revel in the rich, comforting, and zesty flavors of the Southwest.